Emerging therapies for pulmonary hypertension
نویسندگان
چکیده
منابع مشابه
Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
Pulmonary hypertension (PH) is an enigmatic vascular disorder characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, ultimately resulting in pressure overload, dysfunction, and failure of the right ventricle. Current medications for PH do not reverse or prevent disease progression, and current diagnostic strategies are suboptimal for detecting early-stage di...
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Primary pulmonary hypertension (PPH) is a rare condition characterized by neointimal vascular occlusion of small pulmonary arteries that leads to circulatory failure and death (1–3). Severe pulmonary arterial hypertension with identical pathologic obliteration of the pulmonary vasculature is also seen in patients with familial pulmonary hypertension, human immunodeficiency virus, liver cirrhosi...
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Heart failure is associated with high morbidity and mortality and is proving to be an economic burden in developing countries. A number of therapeutic agents are presently employed in heart failure; but they are not sufficient to control symptoms of heart failure. Moreover, the prevalence of chronic heart failure is progressively increasing and thus there is a continuing need to develop effecti...
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The inhaled route has a number of attractive features for treatment of pulmonary hypertension, including delivery of drug directly to the target organ, thus enhancing pulmonary specificity and reducing systemic adverse effects. It can also improve ventilation/perfusion matching by dilating vessels supplying ventilated regions, thus improving gas exchange. Furthermore, it can achieve higher loca...
متن کاملNew therapies for pulmonary hypertension
Pulmonary hypertension was once considered a progressive fatal disease for which there was no effective therapy. Over the past two decades, however, several new drugs have been developed that are effective in improving symptoms, exercise tolerance, and survival. Based on observations made during cardiac catheterization in the 1950s and 60s, pulmonary hypertension was perceived to be a disease o...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)00468-6